The Spaniard had strapping on his left wrist when playing earlier in the tournament; as a result due to doctors advice, he has withdrawn from both matches.
As a result he has been substituted under the Laver Cup rules; with Stefanos Tsitsipas in the doubles match which sees Roger Federer team up with the Greek ace to face off against Isner/Sock.
A previous tie that was going to be very much open now; isn't as much with the latter team unbeaten in Laver Cup action before and are a well-known pairing in their own right in doubles.
Dominic Thiem will be the player to replace Nadal in the singles taking away the tantalising proposition of a tie against Nick Kyrgios; with both players not being the best of friends in the past going back to their clash at Wimbledon.
Thiem has played one match in singles so far downing Denis Shapovalov in a brilliant tie to start the competion off on Friday. Can he repeat the feat against the Aussie ace?
Two other matches will take place as well with Roger Federer and John Isner fresh from their doubles tie facing off in singles. Federer will hope to harness the crowd to potentially get closer to the winning mark with it currently standing at 7-5 to Europe.
Then it is Alexander Zverev against Milos Raonic. The German has played seven matches to Raonic's one in the tournament so that experience might count for something against the Canadian who he is currently 2-1 down to in Head to Head.
https://twitter.com/LaverCup/status/1175694905806643200