The quarterfinal day in New York began with an only match of 2 seeded players. No. 6 Miomir Kecmanovic faced the fourth-seeded Ugo Humbert. After winning the 2020 ASB Classic, Humbert's form got worse but he managed to win the first set against Kecmanovic. However, the Serbian managed to win the next two sets to book his semifinal spot at the New York Open.
Kyle Edmund was another seeded player in New York who managed to turn the match. He faced an in-form playing Soon-Woo Kwon who defeated Milos Raonic in the second round. The Korean managed to win the first set 6-3 but the other two were directed by Edmund.
Jason Jung followed the trend set by Edmund and Kecmanovic and added another three-set match. And again he started by losing the first set. Jung faced 2019 champion Reilly Opelka and after an hour and 53 minutes, he managed to win 5-7, 6-4, 6-4.
The day full of turns of the matches was ended by Andreas Seppi. Jordan Thompson who faced an experienced Italian managed to win the first set 7-6. However, Seppi wanted to repeat what all of the other semifinalists managed to do and he succeeded in doing so. World no. 98 managed to win the second set 6-4 and dominated in third by winning it 6-1 to book his semifinal spot.
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