Musetti who is reigning champion in Hamburg cruised past Swedish ace Elias Ymer 6-4, 6-1. He won 76% of his first-serve points and broke Ymer's serve on five occasions en route to victory in an hour and 16 minutes.
"It took a little bit to get the momentum going. It was not easy because the opponent was playing well, pretty aggressive from the beginning," Musetti said.
"In the end I think I found the right balance, the right rhythm. I have good memories from last year and I am really feeling good here."
While Alexander Zverev despite allegations being his main talking point is still having success on the tennis court.
He saw off Alex Molcan 6-0, 6-3 to seal his 50th tour-level win against left handed players. He did not face a break point en route to reaching the second round and will now face Maximilian Marterer, his compatriot.
Zverev is a two-time semi-finalist in Hamburg and will aim to finally seal the title this week.
Arthur Fils also who had a four match losing streak sealed victory over Daniel Elahi Galan 7-5, 7-5 on his Hamburg debut. While Alejandro Davidovich Fokina saw off Pedro Cachin 2-6, 7-5, 6-2 in an impressive day for the big names.
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