Lopez breezed through Pierre-Hugues Herbert who came through qualifying in a 6-4, 6-3 victory in just over an hour as he got his clay court season underway.
86% of 1st serve points and 64% of second serve were claimed by Lopez with 2/7 break points converted by the Spaniard who will now take on Guido Pella.
Thompson edged past John Millman in an all-Aussie clash 6-3, 4-6, 7-6 (5) and he will now face Miomir Kecmanovic who vanquished Kei Nishikori on Tuesday.
In the first set, he went 2-0 up taking the early break of serve and was soon 4-1 up despite surviving two break points in doing so. He finally succumbed to a break in his requisite service game in a 13-point salvo which saw Millman convert on his third break point.
Thompson was straight back and went on to sweep through 40-0 on his final service game to win the first.
Similar to the first set but on the other end, Millman went 2-0 up but Thompson hit straight back so they continued on serve.
The first set saw a 13-point game, the second saw 27 exchanged between the pair with Thompson missing five break point opportunities. Millman himself took the break in the final game to win the second 6-4.
Another close deciding set followed with it going all the way to a tiebreak which Thompson took 7-2 to vanquish his compatriot.
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