Djokovic if he gets past the Spaniard could face a tough test in the fourth round in Stan Wawrinka or Kevin Anderson. He could also face Sam Querrey in the second round. Then it could be a repeat of the Western & Southern Open semi-finals later in the tournament; against Daniil Medvedev who will be fifth seed.
Rafael Nadal opens his campaign against John Millman; who has giant killing form from last year when he stunned Roger Federer. Nadal will aim to add to his resume at Flushing Meadows; with a potential fourth title. Ties against Fernando Verdasco and John Isner could await the Spaniard also later in the tournament.
Other ties include Felix Auger-Aliassime and Denis Shapovalov meeting in the first round again. Aliassime is into the Top 20 in the rankings; while Shapovalov hasn't had as good a season, it is still an interesting tie.
As is Stefanos Tsitsipas who opens against recent giant-killer Andrey Rublev who handed out an upset to Roger Federer last week. The Greek ace though could face an up-hill battle with Nick Kyrgios potentially in the third round and in-form Roberto Bautista Agut also in his potential future.