Number one seed is Iga Swiatek, she will face Jasmine Paolini in the first round with Greet Minnen and Sloane Stephens - the former champion awaiting the winner.
Emma Raducanu is the defending champion and she will face a well known upset causer in Alize Cornet, while in another standout first round tie - Naomi Osaka will face Danielle Collins.
Serena Williams begins her final ever tournament against Danka Kovinic, while potentially joining her in retirement is her sister, Venus Williams who faces Alison van Uytvanck.
Leylah Fernandez who reached the final last year faces Oceane Dodin, while after losing to her at Wimbledon - Maria Sakkari will get the chance for revenge against Tatjana Maria.
Bianca Andreescu will face another Wimbledon standout in Harmony Tan as she returns to the site of her 2019 triumph aiming to rekindle some form albeit with recent injury worries.
2022 US Open WTA Draw