The draw has been released ahead of BNP Paribas Open Indian Wells which is due to take place between October 7-17 in California.
The recent US Open champion is set to take on either Maria Osorio Serrano or Aliaksandra Sasnovich in the second round.
While Halep could face a tough assignment with Marta Kostyuk, the Ukranian rising star or Shuai Zhang awaiting in the second round.
Top seed is Karolina Pliskova after the Covid-19 withdrawal of Aryna Sabalenka and she will face either Saisai Zheng or Caty McNally in her opener.
ATP Draw released for BNP Paribas Open Indian Wells: Potential quarter final Zverev - Berrettini
While other potential matches include Garbine Muguruza fresh from her Chicago win facing potentially Ajla Tomljanovic. Kim Clijsters facing Katerina Siniakova with Angelique Kerber awaiting.