Matteo Berrettini's bad luck has continued at the US Open after he was forced to retire from his second-round match with an injury and leave the venue in a wheelchair.

The world No. 36 has had a difficult time with injuries as of late but appeared to be coming back to form at Flushing Meadows after he achieved a straight-sets victory over Ugo Humbert in the opening round.

However, Berrettini faced further heartbreak during his second-round match in New York against Arthur Rinderknech. The Italian was already down a set and was trailing 3-5 in the second when he collapsed with an ankle injury and was left writhing on the floor in pain.

As he lay on the ground, Berrettini let out a cry, likely of both physical and emotional pain as he realized that his US Open run had come to an end. Officials rushed to the court to provide aid while others tried to shield the scene from the crowd and cameras with umbrellas.

The 27-year-old managed to get to his feet to shake hands with his opponent and the umpire but had to leave the venue in a wheelchair, holding his head in his hands. Fans have since taken to social media to react to Berrettini's continued injury woes.

"Matteo Berrettini left the US Open in a wheelchair. It’s difficult to explain just how horrific his luck has been. The amount of injuries he’s had just isn’t right. What’s most frustrating is that there’s no one to blame but the universe," wrote The Tennis Letter on X, formerly known as Twitter.

"Was just awful to watch him in so much pain! Love and blessings to him," commented another.

"this man can't get a break. It really feels cruel at this point, it's like universe is saying "no" to his career. Feel sorry for [...] Matteo, i really do. Hope he can recover from this one quickly," added a third.

This comes after Berrettini sustained an abdominal injury that took him out of the Monte-Carlo Masters and forced him to miss the Madrid Open, the Rome Open and the French Open before robbing him of a chance to defend his title at the Queen's Club Championships.